Hello, world
About
My name is Joshua Klein. I am a bioinformatician and a general purpose programmer.
My PhD work was on mass spectrometry informatics for glycomics and glycoproteomics at Boston University's Center for Biomedical Mass Spetrometry. I have written algorithms for low-level signal processing and charge deconvolution, database search + post-processing, feature extraction and more.
After graduation, I worked in the industry for six years at Gritstone bio. In addition to improving immunopeptide identification rates, I was involved in NGS projects for variant calling, target discovery, gene fusion annotation, and proteogenomics. I made deep learning models for predicting MHC antigen presentation and immunogenicity for oncology and infectious disease. I also developed tools for designing multi-antigen mosaic vaccines and for modeling population coverage of therapeutic targets conditioned on the highly polymorphic MHC gene loci and disease-specific target prevalences for the designed vaccines.
For more details, please see my CV.